0015 Biological And Clinical Insights from Genetics of Insomnia Symptoms

Genetics of Insomnia

Despite insomnia being the most common sleep disorder, little is known about the contribution of genetics to its etiology and pathophysiology. Between 6% and 10% of individuals experience insomnia that is chronic in nature, whereas another 25% report occasional difficulties with sleep. Insomnia is also associated with several negative sequelae including fatigue, irritability, and impaired conce...

synthesis of sulfides from alcohols and thiols in solvent-freeconditions and deoxygenation of sulfoxides

کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...

Neuroblastoma tumour genetics: clinical and biological aspects.

Neuroblastoma tumour cells show complex combinations of acquired genetic aberrations, including ploidy changes, deletions of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and-most frequently-gains of chromosome arm 17q. Despite intensive investigation, the fundamental role of these features in neuroblastoma initiation and progression remains to be understood. Nonetheless, grea...

Biological Determinism, Free Will and Moral Responsibility: Insights from Genetics and Neuroscience.

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.

Over the last quarter-century, there has been tremendous progress in genetics research that has defined molecular causes for cardiomyopathies. More than a thousand mutations have been identified in many genes with varying ontologies, therein indicating the diverse molecules and pathways that cause hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies. Translation of this resea...